Mayo Clinic researchers have discovered a new species of bacteria that causes Lyme disease in humans.
The Centers for Disease Control and Prevention announced the discovery of Borrelia mayonii on Monday.
The new bacteria is related to a strain that has long been linked to the disease and was thought to be the only cause of lyme in the U.S. Researchers came across the new bacteria after lab tests from six people with suspected Lyme came back unusual. The bacteria was genetically distinct from the usual suspect.
“Using a laboratory-developed test with a method called ‘melting temperature analysis,’ we detected six specimens that produced a PCR result that was clearly different from B. burgdorferi,” says Bobbi Pritt, M.D., director of the Clinical Parasitology Laboratory at Mayo Clinic who is first author of the study. “Mayo Medical Laboratories, the reference laboratory at Mayo, has tested more than 100,000 patient samples from all 50 states over the past decade using our PCR assay, but we’ve only recently detected evidence of B. mayonii.”
Based on these findings, the researchers believe that the organism may have only recently emerged in the upper Midwestern U.S. “It is possible that this species has been present for even longer but at such low levels that it escaped detection,” adds Dr. Pritt.
As with B. burgdorferi, researchers believe that B. mayonii is transmitted to humans by the bite of an infected black-legged tick (otherwise known as the deer tick). Typical symptoms of Lyme disease include fever, headache, rash, neck pain, and arthritis in later stages. Unlike B. burgdorferi, however, B. mayonii causes an illness that appears to be associated with nausea and vomiting, diffuse rashes (rather than a single bull’s-eye rash), and a higher concentration of bacteria in the blood.
Patients infected with B. mayonii will test positive for Lyme disease with currently available U.S. Food and Drug Administration-cleared Lyme disease tests. In some instances, B. mayonii bacteria also may be seen on a blood smear. “Specific identification of the organism can be made by using the Mayo Clinic PCR test, which detects the DNA of the Lyme disease bacteria,” notes Dr. Pritt.
For treatment, the patients described in the study fully recovered using antibiotics commonly used to treat Lyme disease caused by B. burgdorferi. The CDC recommends that health care providers who are caring for patients infected with B. mayonii also follow the antibiotic regimen described by the Infectious Diseases Society of America.
Dr. Pritt adds, “At this time, there is no evidence that B. mayonii is present outside of the Upper Midwest. However, the public should continue to take the recommended precautions against tick bites, as Lyme disease and other tick-borne diseases are well-established in much of the Northeast.”