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Oldest human DNA found: ‘Spanish fossils’ offer earliest genetic evidence of Neanderthals
Oldest human DNA found: Spanish fossils offer earliest genetic evidence of Neanderthals

Oldest human DNA found: ‘Spanish fossils’ offer earliest genetic evidence of Neanderthals

Researchers have sequenced the oldest human DNA found in a fossil dating back about 430,000.

Recent analysis of mitochondrial DNA from the bones indicated that these Middle Pleistocene hominins were distantly related to the Denisovans, who lived in Asia, despite their Neanderthal-derived features.

Until now it has been unclear how the 28 400,000-year-old individuals found at the Sima de los Huesos (“pit of bones”) site in Northern Spain were related to Neandertals and Denisovans who lived until about 40,000 years ago. A previous report based on analyses of mitochondrial DNA from one of the specimens suggested a distant relationship to Denisovans, which is in contrast to other archaeological evidence, including morphological features that the Sima de los Huesos hominins shared with Neandertals.

“Sima de los Huesos is currently the only non-permafrost site that allow us to study DNA sequences from the Middle Pleistocene, the time period preceding 125,000 years ago”, says Matthias Meyer of the Max Planck Institute for Evolutionary Anthropology, lead author of an article that was published in Nature today. “The recovery of a small part of the nuclear genome from the Sima de los Huesos hominins is not just the result of our continuous efforts in pushing for more sensitive sample isolation and genome sequencing technologies”, Meyer adds. “This work would have been much more difficult without the special care that was taken during excavation”.

New techniques and precise work make the difference

“We have hoped for many years that advances in molecular analysis techniques would one day aid our investigation of this unique assembly of fossils”, explains Juan-Luis Arsuaga of the Complutense University in Madrid, Spain, who has led the excavations at Sima de los Huesos for three decades. “We have thus removed some of the specimens with clean instruments and left them embedded in clay to minimize alterations of the material that might take place after excavation.” The nuclear DNA sequences recovered from two specimens secured in this way show that they belong to the Neandertal evolutionary lineage and are more closely related to Neandertals than to Denisovans. This finding indicates that the population divergence between Denisovans and Neandertals had already occurred by 430,000 years ago when the Sima de los Huesos hominins lived.

According to Svante Pääbo of the Max Planck Institute for Evolutionary Anthropology “these results provide important anchor points in the timeline of human evolution. They are consistent with a rather early divergence of 550,000 to 750,000 years ago of the modern human lineage from archaic humans”.

Consistent with the previous study, the mitochondrial DNA of the Sima de los Huesos hominins is closer related to Denisovans than Neandertals. Mitochondrial DNA seen in Late Pleistocene Neandertals may thus have been acquired by them later in their history, perhaps as a result of gene flow from Africa. The researchers propose that retrieval of further mitochondrial and nuclear DNA from Middle Pleistocene fossils could help to clarify the evolutionary relationship between Middle and Late Pleistocene hominins in Eurasia.

Agencies/Canadajournal




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